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EXTRACT. “Poor medication adherence—defined as any deviation from the prescribed course of medical treatment – is a significant source of waste in our health care system. An estimated one third to one half of all patients in the U.S. do not take their medications as prescribed by their doctors. In addition to compromising care quality, NEHI now estimates the current cost of drug-related morbidity, including poor adherence, to be as much as $290 billion annually—or 13 percent of total health care expenditures.<br /><br />NEHI has identified the four most promising solutions for public and private policymakers to pursue in addressing the issue of medication adherence as part of health reform efforts, including:<br /><br /><ul><li>Creating Health Care Teams</li><li>Patient Engagement and Education</li><li>Payment Reform</li><li>Leveraging Health Information Technologies</li></ul>